Estradiol (pg/mL)

For premenopausal women in the follicular phase, commonly used reference ranges run roughly 30–150 pg/mL, rising far higher around ovulation and falling below about 30 pg/mL after menopause. Because the range shifts with cycle phase, results are interpreted against the day of your cycle at the draw.

It depends on the question. Baseline hormone assessments are typically drawn on cycle day 2–4, when estradiol is at its predictable low; fertility protocols may test at other specific points. Recording your cycle day at the draw makes any result far more interpretable.

In premenopausal women, low estradiol can reflect the normal early-cycle trough, perimenopause, intense exercise with low energy availability, or hypothalamic suppression from stress or undereating. In the menopausal transition, low values alongside high FSH fit the expected pattern. The right interpretation depends on age, symptoms, and cycle timing, worth reviewing with your doctor.

Sometimes. Men produce estradiol by converting testosterone, and levels outside the typical male range (roughly 10–40 pg/mL) are associated with symptoms ranging from low libido to breast tissue changes. It is most often checked in men on testosterone therapy, using a male-specific assay and range.