Current promotion
Lyme Disease Blood Tests: Antibody (IgG/IgM) & DNA Panels
Antibody and DNA testing that screens for exposure to the tick-borne bacterium associated with Lyme disease.
Affiliate disclosure: we earn a commission when you purchase lab tests through links on this site, at no extra cost to you. Learn more
Individual tests from $60.95 (from $48.76 with the promotion applied); multi-test panels from $246.95. Promotional pricing at time of writing.
At a glance
Lyme disease blood testing measures IgM and IgG antibodies and bacterial DNA associated with Borrelia burgdorferi, the bacterium transmitted through tick bites. These panels are designed for people who spend time outdoors, live in tick-prone regions, or are tracking unexplained symptoms such as rash, flu-like illness, fatigue, or joint pain after possible tick exposure. Because many people never notice the bite itself, lab results give you and your doctor objective data to review together.
Best suited for
- Outdoor enthusiasts, hikers, campers, gardeners, hunters, and trail runners, in tick-prone regions
- Anyone with a known or suspected tick bite, including people who never saw a rash
- People tracking unexplained flu-like symptoms, persistent fatigue, or joint pain to discuss with their doctor
- Those who had a positive initial screen and want IgG/IgM immunoblot results for a follow-up conversation
- People whose clinician has recommended repeat antibody testing to follow markers over time
What's included
Lyme and Tick Borne Panel
Serum panel, 4 tests covering 23 tick-borne biomarkers
Lyme Disease IgG IgM Antibodies Immunoblot Test
Measures IgM (recent exposure) and IgG (past or ongoing exposure) antibodies to Borrelia burgdorferi, 15 biomarkers
Lyme Disease IgG Antibody Immunoblot Test
Measures IgG antibodies, which usually appear weeks after infection, 11 biomarkers
Lyme Disease DNA Qualitative Blood Test
Screens for Borrelia burgdorferi genetic material associated with active infection
Lyme Disease - Direct and Indirect Panel
Combines DNA (direct) and antibody (indirect) testing, 2 tests, 17 biomarkers
Borrelia burgdorferi DNA Qualitative Test
Qualitative DNA detection of Borrelia burgdorferi
The importance of testing
Lyme disease stems from Borrelia burgdorferi, a bacterium transmitted through tick bites, and many people who develop symptoms never recall being bitten. Blood testing provides objective data in two complementary ways: immunoblot tests measure IgM antibodies (associated with recent exposure) and IgG antibodies (which typically appear weeks after infection and can persist for months to years), while DNA tests screen directly for the bacterium's genetic material in blood.
Early symptoms associated with Lyme disease, fever, chills, fatigue, body aches, and headache, can closely mimic the flu, and the classic bull's-eye rash does not appear in every case. That overlap is exactly why lab data is useful: antibody and DNA results add a layer of clarity that symptoms alone cannot, and combined options like the Lyme Disease Direct and Indirect Panel pair both approaches in a single order for your doctor to interpret alongside your exposure history.
Testing can also be useful over time. Repeat antibody testing lets you and your clinician track how markers change during and after a care plan, and the broader Lyme and Tick Borne Panel screens 23 biomarkers across four tests for people who want wider tick-borne coverage. Whatever your results show, bring them to your doctor, interpretation depends on the timing of exposure, your symptoms, and which test was run.
Promo code
LYME25Save 20-25% with code LYME25, current promotion; confirm final pricing on the partner page.
Ready to get your numbers? Order online, visit a nearby draw site, and receive private results to review with your doctor.
Order NowFrequently asked questions
What does a Lyme disease blood test measure?
A Lyme disease blood test measures either antibodies your immune system makes against Borrelia burgdorferi or the bacterium's own DNA. Immunoblot tests report IgM antibodies, associated with recent exposure, and IgG antibodies, which usually appear weeks after infection and can persist for months to years. DNA tests screen blood directly for bacterial genetic material. Your doctor interprets results alongside your symptoms and exposure history.
Can I order Lyme disease testing without a doctor's visit?
Yes, these tests can be ordered online in a few clicks, and you then visit a local lab for your blood draw, no doctor's appointment required to place the order. Testing is confidential, and results are delivered to you directly. Any positive or unclear result is worth reviewing with your doctor, who can put it in context and discuss next steps.
What is the difference between the antibody tests and the DNA tests?
Antibody (immunoblot) tests measure your immune response to Borrelia burgdorferi, while DNA tests look for the bacterium's genetic material itself. Because antibodies take time to develop, immunoblots are most informative weeks after exposure; IgM is associated with recent infection and IgG with past or ongoing infection. DNA testing screens for material associated with active infection. The Direct and Indirect Panel combines both approaches in one order.
When should I test after a possible tick bite?
Timing matters because antibody tests detect an immune response that develops over time, IgG antibodies usually appear weeks after infection, so testing too early can miss them. DNA-based tests screen for bacterial genetic material and are used differently in the exposure timeline. If you know when you were bitten or when symptoms began, share that with your doctor so they can help you choose the right test and the right window.
Is there a current discount on Lyme disease testing?
Yes, at the time of writing, the partner page offers 20-25% off Lyme disease testing with promotion code LYME25. That brings the entry-level IgG immunoblot from $60.95 to $48.76, with larger panels discounted proportionally. Promotions change, so confirm the code and final pricing on the partner page before checkout.
Is direct-to-consumer Lyme testing available in every state?
No, direct-to-consumer lab testing is restricted or prohibited in New York, New Jersey, and Rhode Island, so residents of those states may be blocked at the partner's checkout. If you live elsewhere in the US, you can typically order online and complete your draw at a nearby lab location. Check the partner site for participating locations near you.
Related lab test panels
Chronic Fatigue Blood Test Panels: Basic to Comprehensive
Four tiered lab panels that screen the hormonal, nutritional, and metabolic markers most often associated with persistent fatigue.
View panelTuberculosis (TB) Blood Test: QuantiFERON Gold Plus Screening
A single-visit, FDA-approved blood screening for immune markers associated with latent and active TB infection.
View panelHepatitis A & B Blood Tests: Immunity Titers & Infection Screening
Know your hepatitis A and B status, immunity, exposure, or active infection, from a single blood draw.
View panel