Current promotion
Osteoporosis Risk Blood Tests: Bone Turnover & Mineral Markers
Measure the bone turnover, mineral, and hormone markers that shape long-term bone strength.
Affiliate disclosure: we earn a commission when you purchase lab tests through links on this site, at no extra cost to you. Learn more
Bone Essentials Panel $239.16 with code (reg. $298.95); Bone Plus Comprehensive Panel $667.96 (reg. $834.95); individual bone tests from $11.96, promotional pricing at time of writing.
At a glance
The Osteoporosis Risk Assessment is a collection of blood panels and individual lab tests that measure the markers behind bone strength: bone turnover (P1NP, CTX, BSAP, osteocalcin), mineral and vitamin status (vitamin D, calcium, phosphorus, magnesium, PTH), and the thyroid and sex hormones that influence bone remodeling. It is designed for postmenopausal women, men over 50, and adults with risk factors for bone loss who want objective data to review with their doctor. Tests can be ordered online without a doctor's visit, with results often available in 24 to 48 hours.
Best suited for
- Postmenopausal women and men over 50 who want to monitor age-related bone changes
- Anyone with height loss, stooped posture, or a prior low-impact fracture
- People with risk factors such as long-term steroid use, low BMI, smoking, or heavy alcohol use
- Those with thyroid, parathyroid, kidney, or malabsorption conditions, or a family history of osteoporosis
- Adults who want baseline bone health labs to review alongside a DEXA scan
What's included
Bone Essentials Panel (6 tests, 7 biomarkers)
Bone Plus Comprehensive Panel (22 tests, 47 biomarkers)
Bone Specific Alkaline Phosphatase (BSAP) Test
Osteocalcin N-MID Test
PTH Intact Test
QuestAssureD Vitamin D 25-Hydroxy Total Test with D2 and D3
Vitamin D 1,25-Dihydroxy Test
Calcium Test
Phosphate (as Phosphorus) Test
Magnesium Test
Comprehensive Metabolic Panel (CMP)
FSH Test
Testosterone Total Female Test
Testosterone Total Male Test
Serum Protein Electrophoresis (SPEP) Test
Deep-dive the key markers: Vitamin D, Total Testosterone, Estradiol, TSH, eGFR, ALT
Key biomarker ranges
Commonly used adult reference ranges for markers this panel measures, labs vary, so always interpret results against your lab's stated ranges and with your doctor.
Commonly used cutoffs: below 20 ng/mL deficient, 20–30 insufficient, 30–60 a frequently cited target band; season and supplementation move levels substantially.
| Zone | Range |
|---|---|
| Deficient | 0–20 ng/mL |
| Insufficient | 20–30 ng/mL |
| Sufficient | 30–60 ng/mL |
| High | 60–100 ng/mL |
Adult male ranges shown; commonly used reference ranges run roughly 300–1,000 ng/dL, with morning draws the standard since levels peak early in the day.
| Zone | Range |
|---|---|
| Low | 0–300 ng/dL |
| Normal range | 300–1000 ng/dL |
| High | 1000–1200 ng/dL |
Adult female follicular-phase ranges shown; estradiol varies widely across the cycle and drops after menopause, so cycle timing is essential to interpretation.
| Zone | Range |
|---|---|
| Low | 0–30 pg/mL |
| Follicular range | 30–150 pg/mL |
| High | 150–250 pg/mL |
The importance of testing
Bone loss usually develops gradually and without obvious symptoms, which is why many people first learn about it after a fracture. Blood testing offers a window into bone metabolism itself, the ongoing cycle of bone formation and resorption, so you and your doctor can see how your skeleton is being maintained, not just how dense it currently is.
The markers in this assessment fall into three groups. Turnover markers such as P1NP, CTX, bone-specific alkaline phosphatase (BSAP), and osteocalcin reflect how quickly bone is being built and broken down. Mineral and vitamin markers, vitamin D (25-OH), calcium, phosphorus, magnesium, and parathyroid hormone (PTH), show whether your body has the raw materials and regulation needed for bone maintenance. Hormone markers, including thyroid (TSH, free T4/T3), estradiol in women, and testosterone in men, capture the endocrine signals that strongly influence bone remodeling.
Because turnover markers respond to change faster than bone density does, they are useful for tracking trends: a baseline now gives you something concrete to compare against after diet, exercise, supplement, or therapy changes. Morning, fasting samples are often preferred for CTX and P1NP, and results arrive in private, trend-friendly reports, often within 24 to 48 hours.
These labs do not replace a DEXA bone density scan. Instead, they complement one by flagging factors associated with bone loss, such as low vitamin D, abnormal PTH, or hormone shifts, that you can review with your clinician when deciding on next steps.
Promo code
ULTAA95FSave 20% with code ULTAA95F, current promotion; confirm final pricing on the partner page.
Ready to get your numbers? Order online, visit a nearby draw site, and receive private results to review with your doctor.
Order NowFrequently asked questions
Can I order osteoporosis blood tests without a doctor's visit?
Yes, no doctor's visit is needed to place an order, and the lab provides the physician requisition. You order online, visit one of 2,100+ draw sites (most visits take 15 to 30 minutes), and receive private results, often within 24 to 48 hours, to review with your own provider.
Do these blood tests replace a DEXA bone density scan?
No, blood tests complement a DEXA scan rather than replace it. A DEXA scan measures current bone density, while these labs measure bone turnover, mineral, vitamin, and hormone markers associated with bone loss, giving you and your clinician more context about what may be driving any changes.
Which bone health markers should I start with?
A practical baseline includes vitamin D (25-OH), calcium, phosphorus, magnesium, PTH, a comprehensive metabolic panel, TSH, and one bone turnover marker such as CTX or P1NP. Sex hormone tests, estradiol for women, testosterone for men, can be added depending on your age and clinical context, ideally in discussion with your doctor.
Do I need to fast before bone marker testing?
Morning, fasting samples are often preferred for bone turnover markers such as CTX and P1NP. Follow the instructions shown at checkout or your provider's guidance, avoid biotin supplements for 24 to 72 hours before testing if advised, and hydrate normally unless told otherwise.
Is this testing available in every US state?
No, direct-to-consumer lab testing is restricted or prohibited in New York, New Jersey, and Rhode Island, so residents of those states may be blocked at the partner's checkout. Availability and result turnaround can also vary by draw-site location.
Will my insurance be billed?
No, pricing is transparent, cash-pay only, and HSA/FSA cards are accepted. That means no surprise bills, and the price you see at checkout (after any promo code) is what you pay.
Related lab test panels
Vitamin D Blood Test: 25-Hydroxy D Levels & Deficiency Screening
A precise look at your 25-hydroxy vitamin D level, the marker doctors use to assess vitamin D status.
View panelMenopause Blood Test Panels: Hormone & Wellness Lab Testing
Seven lab panels that put numbers behind the hormonal, thyroid, and metabolic shifts of perimenopause and menopause.
View panelWomen's Hormone Blood Test Panel: 12 Essential Markers
Twelve reproductive, thyroid, and adrenal biomarkers from one blood draw, an objective baseline for women's hormonal health.
View panel