Current promotion
Celiac Disease Blood Test: tTG-IgA, DGP & EMA Antibody Panels
Antibody and nutrient panels that screen for celiac-related immune activity and help you track progress on a gluten-free diet.
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Celiac panels from $108.76 with the 20% promotion ($135.95 list); individual tests from $18.36 (promotional pricing at time of writing).
At a glance
Celiac disease blood testing measures antibodies, tissue transglutaminase (tTG) IgA, deamidated gliadin peptide (DGP), and endomysial antibody (EMA), that are typically elevated when the immune system reacts to gluten. The broader panels add markers associated with the nutrient malabsorption and inflammation that can accompany celiac disease, including iron, ferritin, vitamin B12, and vitamin D. This testing is designed for adults with unexplained digestive symptoms, a family history of celiac disease, or a confirmed condition who want to track antibody trends on a gluten-free diet.
Best suited for
- Adults with persistent bloating, gas, diarrhea, or constipation that hasn't resolved with usual changes
- Anyone with a parent, sibling, or child with confirmed celiac disease
- People with unexplained fatigue, anemia, or low iron, B12, or vitamin D results
- Those with confirmed celiac disease who want to track antibody trends on a gluten-free diet
- Adults whose doctor has suggested evaluation for gluten-related digestive, skin, or joint symptoms
What's included
GI-1 Celiac Disease Panel
5 tests, 58 biomarkers
GI-2 Celiac Disease Panel
10 tests, 65 biomarkers
GI-3 Celiac Disease Panel
12 tests, 67 biomarkers
GI-4 Celiac Disease Panel
14 tests, 69 biomarkers
tTG IgA Antibody Test
First-line celiac screening antibody
Immunoglobulin A (IgA) Test
Total IgA to contextualize IgA-based results
Gliadin Deamidated Peptide IgG/IgA Antibodies Test
Endomysial IgA Antibody Screen with Reflex to Titer
Complete Blood Count (CBC) with Differential and Platelets
Comprehensive Metabolic Panel (CMP)
Sed Rate (ESR) Test
C-Reactive Protein (CRP) Test
Vitamin B12 Test
Iron and Total Iron Binding Capacity (TIBC) Test
Ferritin Test
Vitamin D 25-Hydroxy Total Test
Fecal Globin by Immunochemistry Test (InSure)
Deep-dive the key markers: Fasting Glucose, ALT, eGFR, Ferritin, Vitamin D
Key biomarker ranges
Commonly used adult reference ranges for markers this panel measures, labs vary, so always interpret results against your lab's stated ranges and with your doctor.
Commonly used reference ranges place fasting glucose at 70–99 mg/dL; results vary with sleep, stress, and recent illness, and labs differ slightly.
| Zone | Range |
|---|---|
| Low | 50–70 mg/dL |
| Optimal | 70–100 mg/dL |
| Prediabetic range | 100–126 mg/dL |
| Diabetic range | 126–160 mg/dL |
Commonly used cutoffs place ALT below roughly 30–40 U/L, with slightly lower thresholds often cited for women; recent exercise and alcohol can raise results.
| Zone | Range |
|---|---|
| Optimal | 0–30 U/L |
| Borderline high | 30–50 U/L |
| High | 50–100 U/L |
For eGFR, lower is worse: 90+ is consistent with full kidney function, while sustained values below 60 are the commonly used threshold of concern.
| Zone | Range |
|---|---|
| Kidney failure range | 0–15 mL/min/1.73m² |
| Reduced | 15–60 mL/min/1.73m² |
| Mildly reduced | 60–90 mL/min/1.73m² |
| Optimal | 90–120 mL/min/1.73m² |
The importance of testing
Celiac disease is an autoimmune condition in which gluten triggers an immune response that can damage the small intestine, and it often goes unrecognized because its symptoms, bloating, gas, diarrhea or constipation, fatigue, and brain fog, overlap with many other conditions. Antibody testing is the standard first step: the tTG-IgA test is the most widely used screening marker, while DGP and EMA antibody tests add specificity. A total IgA test is typically run alongside, because low overall IgA levels can affect how IgA-based results should be interpreted.
The larger panels on this page go beyond antibodies. A CBC, comprehensive metabolic panel, iron and TIBC, ferritin, vitamin B12, and vitamin D 25-hydroxy testing measure markers associated with the malabsorption that intestinal damage can cause, while sed rate (ESR) and C-reactive protein (CRP) reflect overall inflammatory activity. Reviewed together, these results give you and your doctor a fuller picture than any single test.
For people with confirmed celiac disease, these same antibody tests are used for monitoring: levels tend to decline on a strict gluten-free diet, so retesting over time shows whether antibody trends are moving in the right direction. Tracking nutrient markers at the same time can flag gaps worth discussing as the gut heals.
One practical note: celiac antibody levels reflect ongoing gluten exposure, so starting a gluten-free diet before screening can lower results. Talk with your doctor about timing, and bring any out-of-range results to them for interpretation, lab testing informs that conversation; it does not replace it.
Promo code
GICD20Save 20% with code GICD20, current promotion; confirm final pricing on the partner page.
Ready to get your numbers? Order online, visit a nearby draw site, and receive private results to review with your doctor.
Order NowFrequently asked questions
Can I order celiac disease testing without a doctor's visit?
Yes, these tests can be ordered directly online without a doctor's visit. You choose your panel, pay online, and have your blood drawn at a local lab, with results delivered securely so you can review them with your own physician.
What does the tTG-IgA test measure?
The tTG-IgA test measures IgA antibodies against tissue transglutaminase, a marker associated with the autoimmune response to gluten seen in celiac disease. It is the most widely used first-line celiac screening test, and elevated results are something to review with your doctor for further evaluation.
Why is a total IgA test included with celiac screening?
Total IgA is included because some people naturally produce low levels of IgA, which can make IgA-based celiac tests read falsely low. Knowing your total IgA level helps your doctor interpret the tTG-IgA and EMA results correctly and decide whether IgG-based tests are more informative for you.
Should I keep eating gluten before celiac testing?
Generally yes, celiac antibody tests reflect an active immune response to gluten, so starting a gluten-free diet before screening can lower antibody levels and affect your results. If you have already reduced gluten, talk with your doctor about how that may influence interpretation before you test.
Do these tests confirm celiac disease?
No, these panels screen for antibodies and related markers associated with celiac disease; only a clinician can make that determination, often after additional evaluation. Your results are designed to give you and your doctor concrete data to guide that conversation and any next steps.
Is this testing available in every state?
No, direct-to-consumer lab testing is restricted or prohibited in New York, New Jersey, and Rhode Island, so residents of those states may be blocked at the partner's checkout. Most other US states are supported through a nationwide network of patient service centers.
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