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Gluten Intolerance Testing: Blood Tests for Gluten Sensitivity
Blood panels that screen for the celiac antibodies and nutrient gaps behind gluten-related symptoms.
Affiliate disclosure: we earn a commission when you purchase lab tests through links on this site, at no extra cost to you. Learn more
Celiac panels from $108.76 with the 20% promotion ($135.95 list); individual tests from $18.36 (promotional pricing at time of writing).
At a glance
There is no single blood test that identifies non-celiac gluten sensitivity, gluten intolerance testing starts by screening for celiac disease, the gluten-triggered autoimmune condition that blood tests can detect markers for. These panels measure celiac-related antibodies (tTG-IgA, DGP, and EMA) alongside nutrient and inflammation markers such as iron, ferritin, vitamin B12, vitamin D, ESR, and CRP. They are designed for adults with bloating, digestive discomfort, fatigue, or brain fog who want objective data to bring to their doctor.
Best suited for
- Adults who suspect gluten is behind their bloating, gas, or irregular digestion
- People weighing a gluten-free diet who want baseline blood work first
- Anyone with unexplained fatigue, brain fog, or low iron, B12, or vitamin D results
- Those with a family history of celiac disease or other autoimmune conditions
- People whose symptoms persist despite dietary changes and want data to review with their doctor
What's included
GI-1 Celiac Disease Panel
5 tests, 58 biomarkers
GI-2 Celiac Disease Panel
10 tests, 65 biomarkers
GI-3 Celiac Disease Panel
12 tests, 67 biomarkers
GI-4 Celiac Disease Panel
14 tests, 69 biomarkers
tTG IgA Antibody Test
First-line celiac screening antibody
Immunoglobulin A (IgA) Test
Total IgA to contextualize IgA-based results
Gliadin Deamidated Peptide IgG/IgA Antibodies Test
Endomysial IgA Antibody Screen with Reflex to Titer
Complete Blood Count (CBC) with Differential and Platelets
Comprehensive Metabolic Panel (CMP)
Sed Rate (ESR) Test
C-Reactive Protein (CRP) Test
Vitamin B12 Test
Iron and Total Iron Binding Capacity (TIBC) Test
Ferritin Test
Vitamin D 25-Hydroxy Total Test
Fecal Globin by Immunochemistry Test (InSure)
Deep-dive the key markers: Fasting Glucose, ALT, eGFR, Ferritin, Vitamin D
Key biomarker ranges
Commonly used adult reference ranges for markers this panel measures, labs vary, so always interpret results against your lab's stated ranges and with your doctor.
Commonly used reference ranges place fasting glucose at 70–99 mg/dL; results vary with sleep, stress, and recent illness, and labs differ slightly.
| Zone | Range |
|---|---|
| Low | 50–70 mg/dL |
| Optimal | 70–100 mg/dL |
| Prediabetic range | 100–126 mg/dL |
| Diabetic range | 126–160 mg/dL |
Commonly used cutoffs place ALT below roughly 30–40 U/L, with slightly lower thresholds often cited for women; recent exercise and alcohol can raise results.
| Zone | Range |
|---|---|
| Optimal | 0–30 U/L |
| Borderline high | 30–50 U/L |
| High | 50–100 U/L |
For eGFR, lower is worse: 90+ is consistent with full kidney function, while sustained values below 60 are the commonly used threshold of concern.
| Zone | Range |
|---|---|
| Kidney failure range | 0–15 mL/min/1.73m² |
| Reduced | 15–60 mL/min/1.73m² |
| Mildly reduced | 60–90 mL/min/1.73m² |
| Optimal | 90–120 mL/min/1.73m² |
The importance of testing
If gluten seems to trigger your symptoms, the first question worth answering is whether celiac disease is involved. Celiac is an autoimmune condition in which gluten drives an immune response that can damage the small intestine, and its symptoms, bloating, gas, irregular bowel habits, fatigue, and difficulty concentrating, are easy to mistake for general food intolerance. Antibody tests like tTG-IgA, DGP, and EMA screen for markers associated with that autoimmune response, which simple elimination diets cannot reveal.
The results matter in both directions. Elevated celiac antibodies are a clear flag to review with your doctor before making dietary changes. Antibody results that are not elevated, alongside ongoing symptoms, are also useful information, that pattern is worth discussing with your doctor, since non-celiac gluten sensitivity and other digestive conditions are typically evaluated clinically once celiac markers have been checked.
The broader panels add context that symptom-tracking alone cannot: CBC, metabolic, iron, ferritin, B12, and vitamin D results reflect markers associated with nutrient malabsorption, while ESR and CRP reflect inflammatory activity. Together they help you and your doctor see whether your symptoms come with measurable changes in blood work.
One caution before you test: celiac antibody levels reflect ongoing gluten exposure, so going gluten-free first can lower results and muddy the picture. If you are considering an elimination diet, testing beforehand, and discussing timing with your doctor, preserves the most informative baseline.
Promo code
GICD20Save 20% with code GICD20, current promotion; confirm final pricing on the partner page.
Ready to get your numbers? Order online, visit a nearby draw site, and receive private results to review with your doctor.
Order NowFrequently asked questions
Is there a blood test for gluten intolerance?
There is no single blood test that identifies non-celiac gluten sensitivity, gluten intolerance testing starts by screening for celiac disease, which does have measurable blood markers. These panels measure celiac-related antibodies such as tTG-IgA, DGP, and EMA, giving you and your doctor a concrete starting point for evaluating gluten-related symptoms.
What's the difference between celiac disease, gluten sensitivity, and wheat allergy?
Celiac disease is an autoimmune condition with measurable antibody markers, non-celiac gluten sensitivity causes similar symptoms without those markers, and wheat allergy is an immune reaction evaluated with allergy-specific testing. Blood panels like these screen for the celiac-related antibodies, which is typically the first step in sorting out which category fits your symptoms, a distinction to finalize with your doctor.
Can I order this testing without a doctor's visit?
Yes, you can order these tests directly online without a doctor's visit, then have your blood drawn at a local lab. Results are delivered securely, so you can bring them to your own physician for interpretation and next steps.
Should I go gluten-free before testing?
No, it's generally better to test while still eating gluten, because celiac antibody levels reflect ongoing gluten exposure and can drop on a gluten-free diet. If you have already cut gluten, discuss timing and interpretation with your doctor before testing.
Is this testing available in every state?
No, direct-to-consumer lab testing is restricted or prohibited in New York, New Jersey, and Rhode Island, so residents of those states may be blocked at the partner's checkout. Most other US states are supported through a nationwide network of patient service centers.
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