Current promotion
Graves' Disease Antibody Tests: TSI, TPO & Full Thyroid Panels
Antibody-focused thyroid testing that measures the autoimmune markers associated with Graves' disease, orderable online, no referral needed.
Affiliate disclosure: we earn a commission when you purchase lab tests through links on this site, at no extra cost to you. Learn more
TSI antibody test $118.36 and TPO/thyroglobulin antibodies $36.76 after the 20% discount; Graves' panels from $55.96 (promotional pricing at time of writing).
At a glance
Graves' disease antibody testing measures thyroid stimulating immunoglobulin (TSI) along with thyroid peroxidase (TPO) and thyroglobulin (TgAb) antibodies, the autoimmune markers associated with Graves' disease, the most common cause of hyperthyroidism. It is for adults whose thyroid hormone results look off, who have symptoms such as rapid heartbeat, weight loss, or eye changes, or who are tracking autoimmune thyroid markers with their doctor. Options range from a standalone TSI test to 17-test panels that pair antibodies with a full thyroid and metabolic workup.
Best suited for
- People whose TSH, Free T3, or Free T4 results came back abnormal and who want antibody data before their next doctor's appointment
- Adults with symptoms associated with Graves' disease, rapid or irregular heartbeat, unexplained weight loss, anxiety, bulging eyes, or an enlarged thyroid, seeking measurable markers to review with a clinician
- Anyone with a family history of autoimmune thyroid conditions who wants to screen for TSI, TPO, and thyroglobulin antibodies
- People already managing a thyroid condition with their doctor who want convenient antibody and hormone monitoring between visits
What's included
TSI Test
Thyroid stimulating immunoglobulin, a marker associated with Graves' disease
Thyroid Peroxidase and Thyroglobulin Antibodies Test
TPO and TgAb autoimmune markers
TH-1 Graves' Disease Panel
3 tests: TSH, Free T3, Free T4
TH-2 Graves' Disease Panel
13 tests, 76 biomarkers
TH-3 Graves' Disease Panel
15 tests, 79 biomarkers, thyroid function plus autoimmune markers
TH-4 Graves' Disease Panel
17 tests, 81 biomarkers, the most comprehensive option
TSH Test
Thyroid stimulating hormone (thyrotropin)
T4 Free Test
Free thyroxine (FT4)
T3 Free Test
Free triiodothyronine (FT3)
T3 Reverse Test
Reverse T3 (rT3), an inactive form of T3
Thyroid Foundation Panel
13 tests, 23 biomarkers
Thyroid Foundation Panel Plus Thyroid Panel Add-On
15 tests, 78 biomarkers
Key biomarker ranges
Commonly used adult reference ranges for markers this panel measures, labs vary, so always interpret results against your lab's stated ranges and with your doctor.
Commonly used reference ranges run roughly 0.4–4.0 µIU/mL; TSH moves inversely to thyroid activity, and time of day, illness, and biotin can skew results.
| Zone | Range |
|---|---|
| Low | 0–0.4 µIU/mL |
| Normal range | 0.4–4 µIU/mL |
| Mildly elevated | 4–6 µIU/mL |
| High | 6–10 µIU/mL |
Commonly used reference ranges run roughly 2.3–4.2 pg/mL; Free T3 is best interpreted alongside TSH and Free T4 rather than in isolation.
| Zone | Range |
|---|---|
| Low | 0–2.3 pg/mL |
| Normal range | 2.3–4.2 pg/mL |
| High | 4.2–6 pg/mL |
Commonly used reference ranges run roughly 0.8–1.8 ng/dL; Free T4 shows thyroid hormone supply, while TSH shows the pituitary’s demand signal.
| Zone | Range |
|---|---|
| Low | 0–0.8 ng/dL |
| Normal range | 0.8–1.8 ng/dL |
| High | 1.8–3 ng/dL |
The importance of testing
Standard thyroid tests tell you whether hormone levels are off; antibody tests add evidence about why. TSI is an antibody that stimulates the thyroid gland, and elevated levels are a marker associated with Graves' disease, an autoimmune condition that is the leading cause of hyperthyroidism. TPO and thyroglobulin antibodies target the enzymes and proteins the thyroid uses to make hormone, and high levels are linked to autoimmune thyroid activity more broadly. Together, these markers give your doctor important context that hormone levels alone cannot provide.
Antibody results are most informative alongside the core hormone trio, TSH, Free T4, and Free T3. A suppressed TSH with elevated free hormones is a pattern associated with an overactive thyroid, and adding TSI to that picture helps clarify whether an autoimmune process may be involved. That is why the Graves'-focused panels in this collection (TH-1 through TH-4) combine antibodies with hormone testing, with the largest covering 81 biomarkers including metabolic and nutritional markers.
These markers are also worth tracking over time. Repeating antibody and hormone testing shows whether levels are rising, stable, or falling, useful data if you and your clinician are following a care plan or watching for changes after an earlier result. Bring your numbers to your appointments: lab results are a starting point for that conversation, not a medical conclusion on their own.
Promo code
THHYPER20Save 20% with code THHYPER20, current promotion; confirm final pricing on the partner page.
Ready to get your numbers? Order online, visit a nearby draw site, and receive private results to review with your doctor.
Order NowFrequently asked questions
What blood test screens for Graves' disease antibodies?
The thyroid stimulating immunoglobulin (TSI) test measures the antibody most closely associated with Graves' disease. TSI antibodies stimulate the thyroid gland, and elevated levels can accompany symptoms such as weight loss, rapid heartbeat, or eye problems. Doctors also use TPO and thyroglobulin antibody tests to assess autoimmune thyroid activity more broadly, so many people order antibodies alongside TSH, Free T3, and Free T4.
What is the difference between TSI and TPO antibodies?
TSI antibodies stimulate the thyroid and are the marker most specifically associated with Graves' disease, while TPO and thyroglobulin antibodies target the enzymes and proteins used in hormone production and are linked to autoimmune thyroid disorders in general, including both Hashimoto's thyroiditis and Graves' disease. Measuring both gives your doctor complementary information about what may be driving abnormal hormone levels.
Can I order Graves' disease antibody tests without a doctor's referral?
Yes, these tests are sold through a direct-access lab testing partner, so you can order online and provide a blood sample at a local draw site without a referral. Results come back quickly and are delivered directly to you, and anything out of range is worth reviewing with your doctor.
Should I test antibodies alone or as part of a full panel?
Antibody results are most useful when paired with hormone levels, so a combined panel is generally the more informative choice. The Graves'-focused panels here pair TSI and other markers with TSH, Free T3, and Free T4, and the larger versions add metabolic, blood-health, and nutritional markers, up to 81 biomarkers in the most comprehensive option. A standalone TSI test can make sense if your hormone levels were tested recently.
Is this testing available in every US state?
No, direct-to-consumer lab testing is restricted or prohibited in New York, New Jersey, and Rhode Island, so residents of those states may be blocked at the partner's checkout. Residents of other US states can typically order online and use a nearby draw location.
Related lab test panels
Hypothyroidism & Hashimoto's Blood Tests: TSH, Free T4 & Antibodies
Thyroid hormone and antibody testing in one place, from a single TSH check to comprehensive 17-test panels.
View panelThyroid Function Blood Test Panels: TSH, Free T4 & Free T3
From a basic TSH and T4 screen to a full antibody workup, thyroid panels for every level of detail.
View panelThyroid Blood Test Panels: TSH, Free T4, Free T3 & Antibodies
From a basic TSH check to a full antibody workup, a complete menu of thyroid tests and panels, currently 20% off.
View panel